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Rapid rescreen: a viable alternative to 1:10?

N Dudding1

  • 1Northern Yorkshire Regional Cytology Training School, Morley, West Yorkshire, UK. nickd@pathology.leeds.ac.uk

Diagnostic Cytopathology
|March 10, 2001
PubMed
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Rapid Pap smear screening effectively identified over half of abnormal cases, including high-grade lesions. This quality control method shows superiority over traditional 1:10 rescreening, questioning its continued use in cytology.

Area of Science:

  • Cytopathology
  • Cervical Cancer Screening
  • Quality Control in Laboratories

Background:

  • UK laboratories require rapid screening of normal Pap smears for quality control.
  • US standard quality control (QC) uses 1:10 and selective rescreening procedures.
  • This study evaluates rapid screening as an alternative QC method.

Purpose of the Study:

  • To assess the effectiveness of rapid screening for identifying abnormal Pap smears.
  • To compare rapid screening performance against traditional 1:10 rescreening.
  • To evaluate the role of rapid screening in cervical cytology quality control.

Main Methods:

  • Forty participants performed rapid screening of 50 Pap smear slides each.
  • Slides were screened within a 60-second time limit per slide.

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  • Thirty slides contained "false negative" abnormal cells (originally called negative/unsatisfactory).

    • Main Results:

    • Rapid screening correctly identified 54% of atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LGSIL) cases.
    • Sixty-one percent of high-grade squamous intraepithelial lesion (HGSIL) cases were correctly identified.
    • Individual performance varied, but overall results indicated significant detection rates.

    Conclusions:

    • Rapid screening demonstrates superior performance compared to the 1:10 rescreening method.
    • The findings challenge the continued use of outdated 1:10 rescreening practices in cervical cytology.
    • Rapid screening offers a potentially more effective quality control measure for Pap smears.