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Pleural Effusion Cytology of Metastatic Sclerosing Epithelioid Fibrosarcoma

Daniel W Masters1, Jan F Silverman1

  • 1Department of Pathology and Laboratory Medicine, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.

Diagnostic Cytopathology
|July 3, 2026
PubMed

Keywords:
MUC4cytologymalignant effusionpleural effusionsclerosing epithelioid fibrosarcoma

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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations: