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[Cladosporiosis in chronic herpetic encephalomyelitis]
1Minsk State Medical Institute, City Bureau of Pathology, 220798, Minsk.
Abstract:
One case of chronic herpetic meningoencepalitis complicated by a rare my costs of the central nervous system (CNS) and generalised viral infection is described. Cladosporiosis is considered as a lesion resulting from a immunosuppression due to chronic herpetic involvement of CNS. Morphologically this mycosis is manifested by the presence of spors and septic micelium among cells of productive inflammation an inside of giant multinuclear cells in affected areas. Viral nature of the encephalomyelitis is documented by presence of typical intranuclear inclusions and detection of herpetic antigen by means of fluorescent antibodies.
Insights
A rare central nervous system (CNS) fungal infection, cladosporiosis, complicated a patient with chronic herpetic meningoencephalitis. This case highlights CNS immunosuppression due to herpes simplex virus leading to opportunistic fungal infections.
Area of Science:
- Neurology
- Infectious Diseases
- Mycology
Background:
- Chronic herpetic meningoencephalitis can lead to central nervous system (CNS) immunosuppression.
- Opportunistic infections may arise in immunocompromised individuals.
Observation:
- A rare case of central nervous system (CNS) cladosporiosis is described.
- The cladosporiosis complicated a patient with chronic herpetic meningoencephalitis and generalized viral infection.
Findings:
- Morphological analysis revealed fungal spores and mycelium within inflammatory cells and multinucleated giant cells.
- Viral etiology was confirmed by intranuclear inclusions and detection of herpetic antigen using fluorescent antibodies.
Implications:
- This case suggests CNS immunosuppression from chronic herpes simplex virus infection can predispose to rare fungal infections like cladosporiosis.
- Highlights the importance of considering opportunistic mycoses in patients with chronic CNS viral infections.