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Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma
S D Eggers1, D R Salomao, R P Dinapoli
1Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA.
Mayo Clinic Proceedings
|March 13, 2001
Abstract:
Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.