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Genetic influences on baroreflex function in normal twins.

J Tank1, J Jordan, A Diedrich

  • 1Clinical Research Center, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University, Berlin, Germany.

Hypertension (Dallas, Tex. : 1979)
|March 13, 2001
PubMed
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Baroreflex sensitivity (BRS) is significantly influenced by genetics, with heritability estimates ranging from 36% to 44%. These genetic factors appear independent of body mass index and resting blood pressure.

Area of Science:

  • Cardiovascular Physiology
  • Human Genetics
  • Twin Studies

Background:

  • Blood pressure and heart rate are known to be influenced by genetic factors.
  • The genetic contribution to baroreflex function, a key short-term cardiovascular regulator, remains largely unknown.

Purpose of the Study:

  • To assess the genetic influence on baroreflex sensitivity (BRS).
  • To determine if genetic factors for BRS differ from those for resting blood pressure and BMI.

Main Methods:

  • Studied 149 twin pairs (88 monozygotic, 61 dizygotic).
  • Measured ECG and finger arterial blood pressure continuously at rest.
  • Calculated BRS using cross-spectral analysis (BRSLF, BRSHF) and the sequence technique (BRS+, BRS-).
  • Estimated heritability (h(2)) using path-modeling, comparing monozygotic and dizygotic twin data.

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Main Results:

  • BRS values did not differ significantly between monozygotic and dizygotic twins.
  • Significant correlations for BRS were found in monozygotic but not dizygotic twin pairs.
  • Heritability estimates for BRS ranged from 0.36 to 0.44 (P < 0.01).
  • Genetic influence on BRS remained significant after correcting for BMI and blood pressure.

Conclusions:

  • Baroreflex sensitivity (BRS) is substantially heritable.
  • Genetic factors significantly contribute to BRS variability.
  • The genetic determinants of BRS are likely distinct from those influencing resting blood pressure and BMI.