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[A study on the relationship among activity of PDGFBB autocrine loop, cell proliferation and apoptosis in human
1Department of Neuropathology, Neurology Institute, Tianjin Medical University Hospital, Tianjin 300052.
Objective:
To investigate the relationship between activity of autocrine loop of platelet-derived growth factor BB (PDGFBB), cell proliferation and apoptosis in gliomas.
Methods:
73 human gliomas with different degrees of malignancy were studied using in situ hybridization, in situ cell death detection (TUNEL method) and immunohistochemistry.
Results:
The activity of PDGFBB autocrine loop and cell proliferation in gliomas correlated positively with each other and increased with the degree of tumor malignancy. Apoptosis decreased with the increase of malignancy and correlated negatively with the activity of PDGFBB autocrine loop as well as proliferation in glioma cells.
Conclusion:
These results suggest that all the above parameters have referential value in the evaluation of biological behavior of gliomas. Abnormal increase of activity of PDGFBB autocrine loop in glioma cells may be an important factor which stimulates cell proliferation and inhibits cell apoptosis and plays an important role in the development and progression of gliomas.
