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Secretoneurin and neurogenic inflammation
C J Wiedermann1, S Dunzendorfer, C M Kähler
1Laboratory of Intensive Care Medicine, Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. Christian.Wiedermann@uibk.ac.at
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|March 14, 2001
Summary
Secretoneurin, a peptide involved in neurogenic inflammation, is synthesized in spinal ganglia and activates cell functions. This sensory neuropeptide shows potential for modulating inflammatory reactions.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Secretoneurin is a 33-amino acid polypeptide derived from secretogranin II.
- Its role in neurogenic inflammation requires further investigation.
Purpose of the Study:
- To review evidence for secretoneurin's role in neurogenic inflammation.
Main Methods:
- Literature review utilizing the MEDLINE database.
Main Results:
- Secretoneurin is synthesized in spinal ganglia and released from primary afferent neurons.
- It acts as an excitatory transmitter, activating cell migration (monocytes, eosinophils, fibroblasts, smooth muscle cells, endothelial cells).
- Secretoneurin receptors are G-protein linked, with effects modulated by protein kinase C.
Conclusions:
- Secretoneurin exhibits diverse actions, similar to tachykinins.
- It is a sensory neuropeptide with potential modulatory functions in neurogenic inflammation.