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Effects of S-21007, a potent 5-HT3 partial agonist, in mouse anxiety
P Delagrange1, R Misslin, T W Seale
1Institut de Recherches Internationales Servier, 92415 Courbevoie, France. librext@francenet.fr
Aim:
To study the effect of S-21007, a 5-HT3 partial agonist in different animal models of anxiety in mice.
Methods:
S-21007 effects were evaluated in the behavior tests after intraperitoneal and oral acute treatment or in the light/dark test after both acute and chronic treatments.
Results:
S-21007 presented anxiolytic-like properties after acute administration in the light/dark box test, the mirrored chamber test, and the elevated plus-maze at low doses 10 ng.kg(-1)-100 micrograms.kg-1, 1-100 micrograms.kg-1 and 10-100 micrograms.kg-1, respectively. In the light/dark box test, S-21007 was active orally after acute treatment at 100 ng.kg(-1)-10 mg.kg-1 and after chronic treatment (14 d) at 1-10 micrograms.kg-1. S-21007 was devoid of sedative or stimulatory effects.
Conclusion:
S-21007 exhibited anxiolytic-like properties. The mechanism of action may be a desensitization of 5-HT3 receptor or an antagonist activity on the 5-HT3 receptors.