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Altered baroreflex gain during voluntary breathing in chronic heart failure
1Pharmacologie Clinique, Hôpital Henri Mondor, Créteil, France. luarence.magnin@psl.ap-hop-paris.fr
European Journal of Heart Failure
|March 14, 2001
Summary
Baroreflex (BR) gain is impaired in chronic heart failure (CHF) patients, showing decreased gain with slower breathing. This suggests a central neural regulation defect in the autonomic nervous system of CHF patients.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Regulation
- Heart Failure Pathophysiology
Background:
- Baroreflex (BR) gain is a critical regulator of cardiovascular homeostasis.
- Chronic heart failure (CHF) is associated with autonomic dysfunction.
- Understanding BR behavior in CHF is crucial for managing the condition.
Purpose of the Study:
- To assess baroreflex (BR) gain in chronic heart failure (CHF) patients.
- To investigate the effect of respiration as a forcing stimulus on BR gain.
- To compare BR gain between CHF patients and healthy controls.
Main Methods:
- Spectral analysis and time-domain methods were used to assess BR gain.
- Recordings of RR interval and arterial pressure fluctuations were obtained.
- Patients performed voluntary paced-breathing at 0.15 Hz and 0.25 Hz.
Main Results:
- BR gain decreased in CHF patients with slower breathing (0.15 Hz).
- BR gain increased in healthy controls with slower breathing.
- A significant difference in BR gain response to breathing frequency was observed between groups.
Conclusions:
- Voluntary breathing significantly impacts cardiovascular controller gain in CHF patients.
- Findings indicate an impairment in central neural regulation of autonomic outflow in CHF.
- This study highlights altered autonomic control mechanisms in chronic heart failure.
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