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Cryo-EM structure of the bicarbonate receptor GPR30

Shota Kaneda1, Airi Jo-Watanabe2, Hiroaki Akasaka1

  • 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Elife
|August 14, 2026
PubMed
Summary

Researchers revealed the structure of the G-protein-coupled receptor 30 (GPR30) bound to bicarbonate. This breakthrough clarifies how GPR30 senses pH changes and aids drug discovery for acid-base imbalance disorders.

Keywords:
GPCRbicarbonate-sensingcryo-EMhumanmolecular biophysicsstructural biology

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