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Immobilization of bisphosphonates on surface modified titanium.
1Department of Dental Materials Science and Oral Health Science Center, Tokyo Dental College, Chiba, Japan. yosinari@tdc.ac.jp
Biomaterials
|March 15, 2001
Summary
Surface modifications enhance bisphosphonate immobilization on titanium, proving safe for bone cells and inhibiting oral bacteria. This innovation is promising for dental implants.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Surface Chemistry
Background:
- Titanium is a common dental implant material.
- Bisphosphonates are used to treat bone diseases.
- Effective immobilization of bisphosphonates on titanium surfaces is crucial for enhanced osseointegration and infection prevention.
Purpose of the Study:
- To investigate the efficiency of surface modifications for bisphosphonate immobilization on titanium.
- To evaluate the biocompatibility and osteogenic potential of bisphosphonate-immobilized titanium.
- To assess the inhibitory effect of modified titanium surfaces on oral bacteria adherence.
Main Methods:
- Surface modification of titanium using Ca-ion implantation and hydroxyapatite coatings.
- X-ray photoelectron spectroscopy (XPS) for surface analysis and bisphosphonate immobilization confirmation.
- In vitro evaluation of osteoblastic cell activity (ALP assay).
- Assessment of initial adherence of Porphyromonas gingivalis (oral bacterium).
Main Results:
- Ca-ion implantation and hydroxyapatite coatings successfully immobilized bisphosphonates onto titanium surfaces.
- Bisphosphonate-immobilized titanium showed no toxic effects on osteoblastic cells, maintaining similar ALP activity to control titanium.
- The modified titanium surfaces demonstrated a favorable microenvironment for osteogenesis.
- Bisphosphonate-immobilized titanium significantly inhibited the initial adherence of P. gingivalis.
Conclusions:
- Surface modification techniques, including Ca-ion implantation and hydroxyapatite coatings, effectively immobilize bisphosphonates on titanium.
- Bisphosphonate-immobilized titanium is biocompatible, supports osteoblastic cell activity, and possesses antibacterial properties against P. gingivalis.
- These findings suggest that bisphosphonate-immobilized titanium holds significant potential for improving dental implant efficacy and reducing peri-implantitis risk.