[Activity of the prostanoids system in inflammatory diseases of the colon]

Content of prostaglandins (PG) E2 and E2 alpha, prostacycline (PC) and tromboxane B2 (TxB2) in plasma of patient's blood with inflammatory diseases of large intestine was studied. In patients with nonspecific ulcerative colitis and Crohn's disease content of PGE2 is increased by 72.1%, PC--is decreased by 57%, TxB2--is increased by 144.8%. Detected changes have pathogenetic significance, their severity correlated with severity of the disease course. Tendency to normalization of the prostanoid system state was noted after performance of complex treatment.