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Updated: Aug 12, 2026

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
Published on: June 4, 2014
The role of the Cdk5--p35 kinase in neuronal development
1Instituto Investigación Médica Mercedes y Martín Ferreyra, (INIMEC-CONICET), Córdoba, Argentina.
Abstract:
Cyclin-dependent kinase 5 (Cdk5) plays a key role in proper development of the nervous system. To be activated, Cdk5 associates with regulatory subunits not related to cyclins, such as p35 (the regulatory subunit of Cdk5). In this article, we review some of the experimental evidence supporting a central role for the Cdk5/p35 kinase in neuronal migration and process formation.
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