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Cervical metastasis from an unknown primary.

M P Fried, W H Diehl, R J Brownson

    The Annals of Otology, Rhinology, and Laryngology
    |March 11, 1975
    PubMed
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    A systematic therapy for cervical metastases from unknown primaries, including radiation and surgery, achieved a 39% three-year survival rate in patients treated for cure. This approach offers hope for long-term survival in these challenging cases.

    Area of Science:

    • Oncology
    • Head and Neck Surgery

    Background:

    • Cervical metastases from unknown primaries represent a significant clinical challenge.
    • Effective treatment strategies are crucial for improving patient outcomes.

    Purpose of the Study:

    • To describe the evaluation and treatment of patients with cervical metastases from unknown primaries.
    • To report the survival rates associated with a systematic therapeutic approach.

    Main Methods:

    • Retrospective analysis of 49 patients treated over an 11-year period.
    • Systematic therapy involved full-course radiation therapy (6000-7000 rads) to primary sites and neck.
    • Radical neck dissection followed radiation for palpable residual nodes.

    Main Results:

    Related Experiment Videos

  • 31 patients (63%) were treated with curative intent.
  • The three-year survival rate for patients treated for cure was 39%.
  • Six of the last 11 consecutive patients treated with the systematic approach achieved long-term survival.
  • Conclusions:

    • A systematic therapeutic approach combining radiation and surgery can yield favorable survival rates for cervical metastases of unknown primary.
    • This strategy warrants consideration for patients with histopathologic diagnoses of epidermoid carcinoma or undifferentiated malignant tumor.