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Triterpenoids from Dysoxylum malabaricum.

A Hisham1, A Bai, G JayaKumar

  • 1Department of Chemistry, College of Science, Sultan Qaboos University, Al-khode, Oman. hisham@squ.edu.om

Phytochemistry
|March 16, 2001
PubMed
Summary

Researchers isolated two novel triterpenes from Dysoxylum malabaricum leaves, alongside eight known compounds. Advanced NMR techniques confirmed the structure of the new apotirucallene triterpenoid.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Organic Chemistry

Background:

  • Dysoxylum malabaricum is a plant species known for its diverse chemical constituents.
  • Triterpenes are a class of organic compounds with a wide range of biological activities.
  • Isolation and characterization of novel compounds contribute to understanding plant chemical diversity.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the leaves of Dysoxylum malabaricum.
  • To identify novel triterpenoids and elucidate their structures.
  • To contribute to the phytochemical knowledge of the Dysoxylum genus.

Main Methods:

  • Extraction of compounds from Dysoxylum malabaricum leaves.
  • Chromatographic techniques for isolation of individual compounds.

Related Experiment Videos

  • Spectroscopic methods including 1H and 13C NMR, 1H-1H COSY, HMQC, and HMBC for structural elucidation.

    • Main Results:

    • Two new triterpenes, 21R,23R-epoxy-21alpha-ethoxy-24S,25-dihydroxyapotirucall-7-en-3-one and 24R-acetoxy-3beta,25-dihydroxycycloartane, were isolated.
    • Eight known compounds including lupeone, lupeol, sitosterol, dipterocarpol, cycloart-25-ene-3beta,24-diol, 24R,25-dihydroxycycloartan-3-one, 3beta,24R,25-trihydroxycycloartane, and ergosta-5,24(24(1))-diene-3beta,4beta,20S-triol were identified.
    • The complete 1H and 13C NMR spectral assignments for the new apotirucallene triterpenoid were successfully achieved.

    Conclusions:

    • The study successfully identified novel and known triterpenoids from Dysoxylum malabaricum leaves.
    • The structural elucidation of the new compounds was confirmed through comprehensive spectroscopic analysis.
    • This research expands the understanding of the phytochemical profile of Dysoxylum malabaricum.