Update to RIFM fragrance ingredient safety assessment, methyl cis-5-octenoate, CAS Registry Number 41654-15-3

Methyl cis-5-octenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl 3-hexenoate (CAS # 2396-78-3) show that methyl cis-5-octenoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to methyl cis-5-octenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that there are no safety concerns for methyl cis-5-octenoate for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; methyl cis-5-octenoate is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; methyl cis-5-octenoate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients (RQs), based on its current volume of use (VoU) in Europe (EU), North America (NA), Asia-Pacific (AP), and Japan (JP), (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1. Methyl cis-5-octenoate was not able to be risk screened for South America (SA) as there was no reported VoU for this region in the 2023 IFRA Survey.