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Related Concept Videos

Aromatic Compounds: Overview01:25

Aromatic Compounds: Overview

In general, the term ‘aromatic’ indicates a pleasant smell or fragrance from fresh flowers, freshly prepared coffee, etc. In the early history of organic chemistry, many benzene derivatives were isolated from the pleasant odor oils of the plants. For example, vanillin was isolated from the oil of vanilla, methyl salicylate from the oil of wintergreen, and cinnamaldehyde from the oil of cinnamon. They all had a pleasant odor; hence the name aromatic was given.
In 1825, Faraday isolated benzene...

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RIFM fragrance ingredient safety assessment, cedrene, CAS Registry Number 11028-42-5.

A M Api1, A Bartlett1, D Belsito2

  • 1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ 07430, USA.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
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Summary

Cedrene demonstrates no genotoxicity and is safe for repeated dose, reproductive, and respiratory toxicity. It is not a skin sensitizer, photoirritant, or environmentally persistent, bioaccumulative, and toxic (PBT) substance.

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Area of Science:

  • Toxicology and Environmental Safety Assessment
  • Chemical Safety and Risk Evaluation
  • Fragrance Ingredient Safety

Background:

  • Cedrene is a chemical compound used in various applications.
  • Comprehensive safety evaluations are crucial for chemical ingredients.
  • Regulatory compliance necessitates thorough toxicological and environmental assessments.

Purpose of the Study:

  • To evaluate the genotoxicity, toxicity, and environmental safety of cedrene.
  • To determine the safety profile of cedrene for human health and the environment.
  • To ensure compliance with International Fragrance Association (IFRA) standards.

Main Methods:

  • Genotoxicity assays were performed.
  • Repeated dose, reproductive, and local respiratory toxicity were assessed using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials.
  • Skin sensitization was evaluated by determining the No Expected Sensitization Induction Level (NESIL).
  • Photoirritation/photoallergenicity was assessed using available data and UV/Vis spectra.
  • Environmental safety was evaluated against PBT criteria and risk quotients based on reported volumes of use (VoU).

Main Results:

  • Cedrene was found to be non-genotoxic.
  • Exposure levels were below the TTC for repeated dose, reproductive, and local respiratory toxicity.
  • A NESIL of 3500 μg/cm2 was established for skin sensitization.
  • Cedrene is not expected to be photoirritating or photoallergenic.
  • Cedrene is not PBT and had risk quotients <1 for EU, NA, AP, and JP.
  • Risk screening for SA was not possible due to lack of reported VoU.

Conclusions:

  • Cedrene is considered safe regarding genotoxicity, repeated dose, reproductive, and local respiratory toxicity.
  • Cedrene does not pose a significant risk for skin sensitization, photoirritation, or photoallergenicity.
  • Cedrene is not Persistent, Bioaccumulative, and Toxic (PBT) and presents a low environmental risk based on current usage volumes.
  • The safety assessment supports the use of cedrene within established guidelines.