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Updated: Jan 15, 2026
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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
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Update to RIFM fragrance ingredient safety assessment, 2-heptanone, CAS Registry Number 110-43-0
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Summary
2-Heptanone demonstrates a favorable safety profile, showing no genotoxicity and acceptable margins of exposure for repeated dose and reproductive toxicity. Environmental and skin sensitization assessments also indicate no safety concerns at current usage levels.
Area of Science:
- Chemical safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- 2-Heptanone is a chemical compound used in various applications.
- Comprehensive safety evaluations are crucial for regulatory compliance and consumer protection.
Purpose of the Study:
- To evaluate the safety of 2-heptanone across multiple toxicological and environmental endpoints.
- To determine potential risks associated with its current declared levels of use.
Main Methods:
- Genotoxicity assays, repeated dose toxicity studies, reproductive toxicity assessments.
- Evaluation of local respiratory toxicity, photoirritation/photoallergenicity, and skin sensitization.
- Environmental safety assessment including PBT criteria and risk quotients (PEC/PNEC).
Main Results:
- 2-Heptanone was found to be non-genotoxic.
- Margins of Exposure (MOE) >100 were calculated for repeated dose and reproductive toxicity.
- No safety concerns were identified for skin sensitization, photoirritation/photoallergenicity, or local respiratory toxicity (via read-across).
- 2-Heptanone is not Persistent, Bioaccumulative, and Toxic (PBT), with environmental risk quotients <1.
Conclusions:
- 2-Heptanone presents no significant safety concerns for genotoxicity, repeated dose toxicity, or reproductive toxicity at current usage levels.
- The compound is not expected to be photoirritating/photoallergenic and poses no risk for skin sensitization.
- Environmental risk assessments indicate that 2-heptanone is not PBT and poses a low environmental risk.
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