Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antisense peptide nucleic acids.

P E Nielsen1

  • 1Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3c, DK-2200 N Copenhagen, Denmark. Pen@imbg.ku.dk

Current Opinion in Molecular Therapeutics
|March 16, 2001
PubMed
Summary

Peptide nucleic acid (PNA) technologies for antisense and antigene applications are advancing rapidly. Improved delivery methods are enabling new preclinical studies in genomics and medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Congenital Chloride Diarrhea: Diagnosis by Easy-Accessible Chloride Measurement in Feces.

Case reports in pediatrics·2016
Same author

Label-free and reagentless electrochemical detection of PCR fragments using self-assembled quinone derivative monolayer: application to Mycobacterium tuberculosis.

Biosensors & bioelectronics·2011
Same author

The measurement of digital systolic blood pressure by strain gauge technique.

Scandinavian journal of clinical and laboratory investigation·2010
Same author

Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer.

Talanta·2008
Same author

Systemic delivery: the last hurdle?

Gene therapy·2005
Same author

The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals.

Journal of biomolecular structure & dynamics·2003

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genomics

Background:

  • Peptide nucleic acid (PNA) antisense and antigene technologies have recently gained traction in biological and preclinical research.
  • Advancements in PNA oligomer delivery to eukaryotic cells have been a key driver for this progress.

Purpose of the Study:

  • To assess the current state and future prospects of PNA antisense and antigene technology.
  • To evaluate the impact of novel delivery methods on PNA-based research.

Main Methods:

  • Development of novel methods for efficient PNA oligomer delivery to eukaryotic cells.
  • Conducting ex vivo studies using PNA technology.
  • Initiating in vivo studies to explore PNA applications.

Main Results:

  • Novel delivery methods have facilitated ex vivo studies on cultured cells.
  • In vivo studies utilizing PNA technology are beginning to emerge.
  • Current understanding is still developing, with some recent findings requiring further explanation.

Conclusions:

  • PNA antisense and antigene technology holds significant promise for functional genomics and medicine.
  • Further research is needed to address unresolved issues and rationalize recent findings.
  • The immediate future is expected to provide a stronger basis for evaluating PNA technology's potential.

Related Experiment Videos