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Related Experiment Videos

Finasteride cream in hirsutism.

K J Lucas1

  • 1Down East Medical Associates, Morehead City, North Carolina 28557, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|March 16, 2001
PubMed
Summary

Topical finasteride cream significantly reduced facial hirsutism in women. This preliminary study found decreased hair count and thickness with no adverse effects, suggesting a potential new treatment for excessive hair growth.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Pharmacology

Background:

  • Hirsutism is characterized by excessive hair growth in women.
  • Androgens, particularly dihydrotestosterone, play a key role in hirsutism.
  • Finasteride inhibits 5α-reductase, an enzyme crucial for androgen conversion.

Purpose of the Study:

  • To evaluate the efficacy of topical finasteride cream in treating facial hirsutism.
  • To assess the impact of finasteride cream on hair growth and thickness.
  • To determine the safety profile of topical finasteride for hirsutism.

Main Methods:

  • A randomized, double-blind, placebo-controlled study.
  • Eight women with facial hirsutism applied finasteride cream (0.25%) or placebo cream to opposite sides of their face.
  • Hair counts and thickness were measured over a 6-month period.

Main Results:

  • Finasteride-treated sites showed a significant decrease in mean hair count (27.5 to 15.5, P<0.05).
  • Mean hair thickness was significantly reduced at finasteride-treated sites (4.33 vs. 3.11, P<0.001).
  • Placebo-treated sites showed no significant changes in hair count or thickness.

Conclusions:

  • Topical finasteride cream effectively reduced hair growth and thickness in women with facial hirsutism.
  • The treatment was well-tolerated, with no adverse effects reported.
  • Topical finasteride presents a promising localized treatment option for hirsutism.

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