Inhibitory neuropeptide receptors on macrophages
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Updated: Oct 9, 2026

Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
1Department of Biological Sciences, Rutgers University, 101 Warren Street, Newark, NJ 07102, USA. dganea@andromeda.rutgers.edu
Abstract:
The immune response, both in innate and adaptive immunity, is controlled at several levels, including signaling from the central nervous system. Neuropeptides released within the lymphoid organs modulate the immune response, either as stimulators or inhibitors. The subject of this review is the description of macrophage-expressed receptors of inhibitory neuropeptides. We describe the inhibitory effects on macrophage function for several neuropeptides, the receptors that mediate those activities, and the molecular mechanisms initiated by some of these receptors in terms of transduction pathways and transcriptional factors.
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