Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgen physiology and the cutaneous pilosebaceous unit.

M G Mercurio1, D S Gogstetter

  • 1University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY 14642, USA.

The Journal of Gender-Specific Medicine : JGSM : the Official Journal of the Partnership for Women'S Health at Columbia
|March 20, 2001
PubMed
Summary

Androgen hormones like testosterone significantly influence hair growth and sebum production. Their overactivity can lead to conditions such as hair loss and acne, impacting psychosocial well-being.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bullous pemphigoid associated with nivolumab, a programmed cell death 1 protein inhibitor.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same author

Treatment of human papilloma virus in a 6-month-old infant with imiquimod 5% cream.

Pediatric dermatology·2001
Same author

Hirsutism: diagnosis and management.

The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia·2001
Same author

Gender and dermatology.

The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia·2001
Same author

Gender-specific medicine and dermatology: clinical implications.

The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia·2001
Same author

Minocycline-induced hyperpigmentation in patients with pemphigus and pemphigoid.

Archives of dermatology·2000

Area of Science:

  • Dermatology and endocrinology, focusing on cutaneous physiology.

Background:

  • Androgen hormones are crucial for pilosebaceous unit function, regulating hair growth and sebum production.
  • Testosterone is converted to dihydrotestosterone (DHT) by 5 alpha-reductase, with DHT mediating most androgenic effects.
  • Elevated androgen activity is linked to common dermatological conditions.

Purpose of the Study:

  • To review the role of androgens in skin physiology.
  • To discuss the mechanisms linking androgens to specific clinical disorders.
  • To highlight the psychosocial impact of androgen-related skin conditions.

Main Methods:

  • Literature review of hormonal regulation in dermatology.
  • Analysis of the biochemical pathways of androgen metabolism.
  • Examination of clinical manifestations and psychosocial effects of androgen excess.

Related Experiment Videos

Main Results:

  • Dihydrotestosterone (DHT) is the primary active androgen mediating effects on the pilosebaceous unit.
  • Increased local androgen production is associated with androgenetic alopecia, hirsutism, and acne.
  • These conditions can cause significant psychosocial distress due to their visibility.

Conclusions:

  • Androgens, particularly DHT, are key regulators of pilosebaceous unit activity.
  • Understanding androgen pathways is vital for managing hair loss, hirsutism, and acne.
  • Addressing the psychosocial aspects of these visible dermatological conditions is important for patient well-being.