Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[TNF alpha and heart failure].

V Pergola1, G Di Salvo, A R Martiniello

  • 1Istituto Medico Chirurgico di Cardiologia, II Università degli Studi, Napoli.

Minerva Cardioangiologica
|March 20, 2001
PubMed
Summary

Tumor necrosis factor alpha (TNF alpha), a proinflammatory cytokine, negatively impacts heart function. Its soluble receptors (sTNF-R1, sTNF-R2) and soluble Fas (sFas) increase in heart failure, suggesting a role in disease progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The changing landscape of multimodality imaging in congenital heart disease: white paper.

European heart journal. Imaging methods and practice·2025
Same author

Elevated mortality risks associated with late diagnosis of cancer in individuals with psychiatric disorders?

Journal of psychiatric research·2024
Same author

Cardioneuroablation: the known and the unknown.

Frontiers in cardiovascular medicine·2024
Same author

FLT3-targeted therapy restores GATA1 pathway function in NPM1/FLT3-ITD mutated acute myeloid leukaemia.

EJHaem·2023
Same author

Effect of bariatric surgery on maternal cardiovascular system.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Evolution of echocardiographic and cardiac magnetic resonance imaging abnormalities during follow-up in patients with multisystem inflammatory syndrome in children.

European heart journal. Cardiovascular Imaging·2022

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Cytokine Signaling

Context:

  • Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with negative inotropic effects on the heart.
  • TNF alpha is implicated in conditions like septic shock, myocarditis, reperfusion injury, and congestive heart failure (CHF).
  • Immune element activation in the heart or periphery likely drives TNF alpha production.

Purpose:

  • To investigate the role of TNF alpha receptors (TNF-R1, TNF-R2) and Fas in congestive heart failure (CHF).
  • To examine the significance of soluble TNF receptors (sTNF-R1, sTNF-R2) and soluble Fas (sFas) in CHF.
  • To explore potential collaborative mechanisms between these receptor systems in heart failure.

Summary:

  • TNF alpha binds to TNF-R1 (cytotoxic, apoptotic) and TNF-R2 (septic shock, lymphocyte proliferation), both mediating negative inotropic effects.

Related Experiment Videos

  • In CHF, TNF-R1 and TNF-R2 are downregulated, while their soluble forms (sTNF-R1, sTNF-R2) increase with symptom severity.
  • Fas, a receptor inducing apoptosis, and its ligand share homology with the TNF system. Soluble Fas (sFas) also increases in heart failure, suggesting a coordinated response.

    • Impact:

    • Increased levels of sTNF-R1, sTNF-R2, and sFas may serve as biomarkers for CHF severity.
    • Understanding the interplay of these receptors could reveal novel therapeutic targets for heart failure.
    • This research highlights the critical role of inflammatory pathways and cytokine signaling in the pathophysiology of CHF.