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Sticking together and sorting things out: adhesion as a force in development.

H McNeill1

  • 1Developmental Patterning Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. h.mcneill@icrf.icnet.uk

Nature Reviews. Genetics
|March 20, 2001
PubMed
Summary

Cellular differentiation requires proper tissue patterning. Differential cell adhesion is a classic hypothesis explaining how cells sort into distinct three-dimensional structures, a process crucial for tissue formation.

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Area of Science:

  • Developmental biology
  • Cell biology
  • Tissue engineering

Background:

  • Proper tissue formation requires not only cell differentiation but also the physical organization of cells into specific three-dimensional structures.
  • Classic hypothesis suggests differential cell adhesion drives tissue patterning, allowing cells to segregate based on affinity differences.
  • Understanding the mechanisms of three-dimensional (3D) patterning is fundamental to developmental biology.

Purpose of the Study:

  • To investigate the classic hypothesis that differential cell adhesion drives tissue patterning during development.
  • To explore the role of cell-cell signaling in establishing differential adhesive properties.
  • To understand how cells physically group into distinct 3D structures.

Main Methods:

Related Experiment Videos

  • Investigated cell sorting mechanisms in model systems like the Drosophila wing.
  • Examined tissue patterning in vertebrate brain development.
  • Focused on identifying signaling pathways that regulate cell adhesion.

    • Main Results:

    • Recent work highlights the essential role of inter-tissue signaling in establishing differential cell affinities.
    • Evidence supports the hypothesis that cell affinity differences contribute to tissue self-organization.
    • Signaling pathways are critical for mediating cell sorting and 3D tissue assembly.

    Conclusions:

    • Inter-tissue signaling is crucial for establishing differential cell affinities, supporting the classic cell sorting hypothesis.
    • The physical grouping of cells into distinct 3D structures is a complex process involving both differentiation and signaling.
    • Further research into cell adhesion and signaling will elucidate fundamental principles of tissue development.