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Genetics and molecular genetics of the MHC
1Department of Pathology, University of Cambridge, UK. drhodes@hgmp.mrc.ac.uk
Reviews in Immunogenetics
|March 21, 2001
Abstract:
The MHC is a well-characterised region of the human genome, containing a high diversity of genes and an apparent clustering of genes involved in the immune response. The genomic sequence of an 8 Mb section, containing the MHC and flanking regions and covering over 300 genes, will soon be available. Since this is a highly polymorphic region, the molecular genetics of the MHC and its relationship with disease have been studied in considerable detail.