Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathways of antigen processing and presentation.

C Watts1, S Powis

  • 1Department of Biochemistry, University of Dundee, UK. c.watts@dundee.ac.uk

Reviews in Immunogenetics
|March 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiparametric MRI and T2/FLAIR mismatch complements the World Health Organization 2021 classification for the diagnosis of IDH-mutant 1p/19q non-co-deleted/ATRX-mutant astrocytoma.

Clinical radiology·2023
Same author

Health utilities for non-melanoma skin cancers and pre-cancerous lesions: A systematic review.

Skin health and disease·2022
Same author

UK food and nutrition security during and after the COVID-19 pandemic.

Nutrition bulletin·2021
Same author

Intervention with Microfinance for AIDS and Gender Equity (IMAGE): Women's Engagement with the Scaled-up IMAGE Programme and Experience of Intimate Partner Violence in Rural South Africa.

Prevention science : the official journal of the Society for Prevention Research·2019
Same author

Evolutionary dynamics of residual disease in human glioblastoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Tests of a full-scale ITER toroidal interferometer and polarimeter (TIP) prototype on the DIII-D tokamak (invited).

The Review of scientific instruments·2018
Same journal

Approaches to managing volunteer marrow donor registry HLA data. Algorithms for directing donor center-initiated HLA-DR typing of selected donors.

Reviews in immunogenetics·2002
Same journal

Data acquisition, data storage, and data presentation in a modern genetics laboratory.

Reviews in immunogenetics·2002
Same journal

The IMGT/HLA sequence database.

Reviews in immunogenetics·2002
Same journal

Bioinformatics: analysis of HLA sequence data.

Reviews in immunogenetics·2002
Same journal

Identifying cytotoxic T cell epitopes from genomic and proteomic information: "The human MHC project.".

Reviews in immunogenetics·2002
Same journal

Storage and utilization of HLA genomic data--new approaches to HLA typing.

Reviews in immunogenetics·2002
See all related articles

T lymphocytes recognize peptide-MHC complexes, assembled intracellularly with chaperone assistance. The stability and surface expression of these complexes are crucial for T cell recognition and can be manipulated by pathogens.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biochemistry

Background:

  • T lymphocytes (CD8+ and CD4+) recognize peptide fragments bound to Major Histocompatibility Complex (MHC) molecules.
  • MHC-peptide complex assembly occurs intracellularly during MHC biosynthesis and trafficking.

Purpose of the Study:

  • To provide an overview of antigen processing and MHC molecule assembly.
  • To discuss the role of accessory molecules and chaperones in MHC-peptide complex formation.
  • To explore mechanisms of MHC-peptide complex stability and pathogen interference.

Main Methods:

  • Review of current literature on cellular biochemistry of antigen processing.
  • Analysis of molecular mechanisms involved in MHC class I and class II assembly.
  • Discussion of pathogen strategies impacting antigen presentation.

Related Experiment Videos

Main Results:

  • MHC-peptide complex assembly involves various intracellular molecules, including dedicated chaperones.
  • Peptide availability influences MHC expression kinetics and surface levels.
  • Pathogens employ diverse strategies to evade T cell recognition by interfering with MHC pathways.

Conclusions:

  • Stable and long-lived MHC-peptide complexes are essential for in vivo T cell recognition.
  • Understanding MHC assembly and antigen processing is key to comprehending immune responses and pathogen evasion tactics.