Related Experiment Videos
Role of reactive oxygen species (ROS) in apoptosis induction
H U Simon1, A Haj-Yehia, F Levi-Schaffer
1Department of Pharmacology, University of Bern, Switzerland.
Abstract:
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.