Related Experiment Video

Updated: Jul 25, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.3K

AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer

E Jensen-Jarolim1,2, H J Bax3,4, R Bianchini1

  • 1The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.

Allergy
|September 19, 2017
PubMed

Insights

AllergoOncology research explores immune tolerance in allergy and cancer. Understanding these shared mechanisms may reveal new therapies benefiting both fields.

Area of Science:

  • Immunology
  • Oncology
  • Allergy Research

Background:

  • Tumor microenvironments often feature immune suppressive cells and mediators, aiding cancer immune escape.
  • Allergen immunotherapy aims to induce tolerance, contrasting with cancer research's goal to break tolerance.

Purpose of the Study:

  • To review immune tolerance insights from allergy and cancer inflammation.
  • To focus on the roles of key immune cells and mediators in both contexts.
  • To propose AllergoOncology as a field to bridge these disciplines.

Main Methods:

  • Literature review of immunological mechanisms in allergy and cancer.
  • Analysis of immune cells and inflammatory mediators.
  • Juxtaposition of clinical consequences in allergy and cancer.

Main Results:

  • Regulatory immune cells and Th2 mediators in tumors can cause immune suppression and tumor escape.
  • Insights from allergy and cancer highlight contrasting roles of immune tolerance.
  • Shared immunological mechanisms exist between allergy and cancer.

Conclusions:

  • Delineating shared mechanisms in AllergoOncology can identify novel therapeutic strategies.
  • Therapeutic interventions may benefit both allergy and cancer treatment.
  • Understanding immune tolerance is crucial for advancing both fields.
Keywords:
allergooncologyallergycanceroncoimmunologytolerance

More Related Videos

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells12:16

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

15.6K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.4K

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

Overview
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.