Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signaling through the B cell antigen receptor in developing B cells.

T M Yankee1, E A Clark

  • 1Primate Center, University of Washington, Seattle 98195-0001, USA. tyankee@u.washington.edu

Reviews in Immunogenetics
|March 22, 2001
PubMed
Summary

B cell development relies on precise signaling through the B cell antigen receptor (BCR). Signal intensity dictates B cell maturation, with defects leading to developmental arrest or apoptosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Suspension Splint, for Treating Simple and Compound Fractures of the Leg.

Chicago medical examiner·2023
Same author

Report of Surgical Cases Treated at the Battles of Pea Ridge and Prairie Grove, Ark.: Primary and Secondary Amputations, Resections, Exsections, Etc., Etc.

The Chicago medical journal·2023
Same author

A Suspension Splint, Etc.

The Chicago medical journal·2023
Same author

A Suspension Splint, for Treating Simple and Compound Fractures of the Leg.

Buffalo medical and surgical journal·2023
Same author

Method of Treating Fractures of the Olecranon Process, and Head of the Humerus.

Buffalo medical and surgical journal·2023
Same author

A Suspension of Splint, for Treating Simple and Compound Fractures of the Leg.

Atlanta medical and surgical journal·2022

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • B cell maturation is a stepwise process regulated by signaling from the B cell antigen receptor (BCR) complex.
  • Expression of BCR components, including heavy and light chains, is crucial for progression through developmental stages.
  • Aberrant signaling or protein deficiencies can halt B cell development, leading to apoptosis or developmental arrest.

Purpose of the Study:

  • To elucidate the critical role of BCR signaling intensity in regulating B cell maturation.
  • To identify the signaling pathways and factors that influence B cell fate during development.

Main Methods:

  • The study focuses on the signaling events initiated by the BCR complex.
  • It examines the impact of signal intensity, antigen concentration, co-receptor ligation, and signaling complex formation on B cell development.
  • Key signaling pathways, including calcium and MAPK pathways, and transcription factor activation are considered.

Main Results:

  • Specific signal intensities through the BCR are required for advancement to distinct B cell maturation stages.
  • Deficiencies in intracellular signaling proteins arrest B cell development.
  • Antigen concentration, co-receptor signaling, and signaling complex assembly modulate signal strength and B cell fate.

Conclusions:

  • BCR signaling dynamics are fundamental to normal B cell development and maturation.
  • The intensity of signals dictates whether a B cell progresses, undergoes repair, or initiates apoptosis.
  • Understanding these signaling mechanisms is key to comprehending B cell homeostasis and potential developmental disorders.

Related Experiment Videos