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Related Experiment Videos

Cardioesophageal reflexes: an invasive human study.

L J Makk1, M Leesar, A Joseph

  • 1Department of Medicine, University of Louisville School of Medicine, Kentucky 40292, USA.

Digestive Diseases and Sciences
|March 22, 2001
PubMed
Summary

Cardiac procedures can trigger esophageal motility issues, particularly in patients with normal coronary arteries. Coronary angioplasty also increases esophageal pain sensitivity.

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Neuroscience

Background:

  • Neural reflex arcs between the esophagus and heart are established in humans and animals.
  • Understanding these connections is crucial for patients undergoing cardiac procedures.

Purpose of the Study:

  • To investigate esophageal-cardiac neural pathways in patients undergoing cardiac catheterization.
  • To assess the impact of cardiac procedures and provocations on esophageal function.

Main Methods:

  • Esophageal manometry and pH monitoring during cardiac catheterization.
  • Esophageal provocation tests (ice water, HCl, balloon inflation) with cardiac monitoring.
  • Correlating findings with coronary artery status and interventions.

Main Results:

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  • Diffuse esophageal spasm occurred in 12 patients with normal coronary arteries during provocation.
  • Coronary angioplasty precipitated esophageal spasm in one patient with abnormal coronaries.
  • Increased esophageal acid sensitivity in normal coronaries vs. abnormal; lower pain threshold post-angioplasty.

Conclusions:

  • Cardiac manipulation can induce esophageal motility abnormalities, but not gastroesophageal reflux.
  • Coronary angioplasty is linked to esophageal hyperalgesia.
  • Esophageal-cardiac reflex pathways are clinically relevant in cardiac patients.