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Bee pollen-induced anaphylactic reaction in an unknowingly sensitized subject
1Division of Allergy-Immunology and the Ernest S. Bazley Asthma and Allergic Diseases Center of Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60611-3008, USA. p-greenberger@northwestern.edu
Summary
Bee pollen, a popular supplement, can trigger allergic reactions like anaphylaxis, even in patients with prior immunotherapy. This case highlights the risk of consuming contaminated bee pollen products.
Area of Science:
- Allergy and Immunology
- Food Science
- Environmental Health
Background:
- Bee pollen is a food supplement with purported health benefits.
- Previous reports indicate bee pollen can cause anaphylaxis.
- This study investigates a case of anaphylaxis from bee pollen ingestion.
Observation:
- An atopic patient experienced a non-life-threatening anaphylactic reaction after initial bee pollen ingestion.
- Skin prick testing showed a positive reaction to bee pollen.
- ELISA inhibition assays demonstrated IgE binding inhibition to common allergens.
Findings:
- Microscopic analysis of the bee pollen revealed contaminants including other pollens (ragweed, honeysuckle, vetch) and fungi (Alternaria, Cladosporium).
- The patient's bee pollen sample showed cross-reactivity with ragweed and ryegrass allergens.
- The patient had previously undergone allergen immunotherapy for rhinitis.
Implications:
- Unknowingly sensitized atopic individuals may react to bee pollen due to contaminants.
- Existing allergen immunotherapy may not prevent reactions to contaminated bee pollen.
- This case underscores the importance of identifying allergens in food supplements to prevent adverse reactions.