Jove
Visualize
Contact Us

Related Experiment Videos

Cytokine-induced sickness behavior: where do we stand?

R Dantzer1

  • 1INRA-INSERM U394, Bordeaux Cedex, 33077, France.

Brain, Behavior, and Immunity
|March 22, 2001
PubMed
Summary

Sickness behavior, driven by brain cytokines like IL-1, involves behavioral changes during infection. This response may link to depression, but the precise connection requires further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum kynurenic acid is reduced in affective psychosis.

Translational psychiatry·2017
Same author

Immunopsychiatry: important facts.

Psychological medicine·2017
Same author

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions.

Molecular psychiatry·2016
Same author

Stress, stereotypies and welfare.

Behavioural processes·2014
Same author

Social and individual recognition in rodents: Methodological aspects and neurobiological bases.

Behavioural processes·2014
Same author

Neuroinflammation and comorbidity of pain and depression.

Pharmacological reviews·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Science

Background:

  • Sickness behavior encompasses coordinated behavioral changes during infection.
  • Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNFalpha), in the brain mediate these changes.
  • Cytokines influence the brain through fast (afferent nerves) and slow (choroid plexus, circumventricular organs) pathways.

Purpose of the Study:

  • To elucidate the molecular mechanisms and behavioral expression of sickness behavior.
  • To explore the role of cytokines in mediating sickness behavior.
  • To investigate the potential link between sickness behavior and depression.

Main Methods:

  • Review of clinical and experimental evidence on sickness behavior.
  • Analysis of molecular pathways involving cytokines (IL-1, TNFalpha).
  • Examination of neural transmission pathways from the periphery to the brain.

Main Results:

  • Sickness behavior is a central motivational state reorganizing organism priorities during infection.
  • Cytokine signaling in the brain is a key molecular driver of sickness behavior.
  • Evidence suggests a link between brain cytokine activation and depression.

Conclusions:

  • Sickness behavior is an adaptive response orchestrated by central cytokine signaling.
  • The precise relationship between sickness behavior and depression remains an area for further research.

Related Experiment Videos