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Responsive polymeric delivery systems.

J Kost1, R Langer

  • 1Department of Chemical Engineering, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel. kost@bgumail.bgu.ac.il

Advanced Drug Delivery Reviews
|March 22, 2001
PubMed
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Responsive polymeric drug delivery systems adjust drug release based on physiological needs. This review examines externally and self-regulated systems, highlighting their use in conditions like diabetes.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Controlled drug delivery is crucial for effective therapy.
  • Responsive polymeric systems offer dynamic control over drug release.
  • Current limitations necessitate advanced delivery strategies.

Purpose of the Study:

  • To review the state of the art in responsive polymeric drug delivery systems.
  • To examine the principles of externally and self-regulated systems.
  • To discuss applications and challenges in specific clinical settings.

Main Methods:

  • Literature review of externally and self-regulated responsive polymeric systems.
  • Analysis of system mechanisms for physiological response.
  • Evaluation of clinical applicability, focusing on diabetes.

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Main Results:

  • Responsive systems can tailor drug release to physiological demands.
  • Both external stimuli-responsive and self-regulated systems show promise.
  • Specific advantages and disadvantages exist for different approaches in clinical use.

Conclusions:

  • Responsive polymeric drug delivery systems represent a significant advancement.
  • Further research is needed to optimize these systems for widespread clinical adoption.
  • Personalized medicine approaches can benefit from these dynamic delivery platforms.