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Bone marrow involvement in cutaneous mastocytosis.
L A Fearfield1, N Francis, K Henry
1Departments of Dermatology and Haematology, Chelsea and Westminster Hospital, London SW10 9NH, U.K. louisefearfield@compuserve.com
The British Journal of Dermatology
|March 22, 2001
Summary
Bone marrow involvement is common in adults with cutaneous mastocytosis, even without systemic symptoms. This study found evidence of bone marrow involvement in most patients with this skin condition.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Cutaneous mastocytosis is typically viewed as indolent.
- Previous estimates suggested limited bone marrow involvement (≤60%) in adults.
Purpose of the Study:
- To determine the frequency of bone marrow involvement in patients with mastocytosis but lacking systemic symptoms.
Main Methods:
- Bone marrow aspirate and trephine biopsy were conducted.
- 13 consecutive patients with cutaneous mastocytosis were included.
Main Results:
- Bone marrow involvement was observed in 12 out of 13 patients.
- All analyzed patients presented with a normal karyotype, despite bone marrow involvement.
Conclusions:
- Bone marrow involvement is a frequent finding in adult cutaneous mastocytosis.
- The study highlights the high prevalence of bone marrow infiltration in this patient group.