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HIV-related Merkel cell carcinoma: A report of three cases from the UK

Evdoxia Panou1, Christos Nikolaou2, Sashini Payagala3

  • 1Departments of Dermatology, 98548University College London Hospitals NHS Foundation Trust, UK.

International Journal of STD & AIDS
|September 16, 2022
PubMed

Insights

Merkel cell carcinoma (MCC), a rare skin cancer, is increasingly diagnosed. This report details three UK cases of MCC in patients with human immunodeficiency virus (HIV), a rare association.

Area of Science:

  • Oncology
  • Dermatology
  • Virology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with increasing incidence.
  • Associated risk factors include Merkel Cell polyomavirus (MCPyV), UV exposure, and immunosuppression.

Observation:

  • Three cases of MCC were diagnosed in patients living with human immunodeficiency virus (HIV).
  • These cases represent the first reported instances of MCC associated with HIV in the United Kingdom.

Findings:

  • The study highlights a rare clinical presentation of MCC in an immunocompromised population.
  • The association between MCC and HIV, while infrequently reported globally, is now documented in the UK.

Implications:

  • This case series expands the understanding of MCC epidemiology in immunocompromised individuals.
  • Further research into the interplay between HIV, MCC, and potential viral co-factors is warranted.
Keywords:
Human immunodeficiency virusviral disease

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