The first acetimine gold(I) and gold(III) complexes and the first acetonine complexes

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

J Vicente1, M T Chicote, R Guerrero

  • 1Departamento de Química Inorgánica, Facultad de Química, Universidad de Murcia, Spain. jvs@um.es

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 23, 2001
PubMed

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Amines to Amides: Acylation of Amines

Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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Structure of Carboxylic Acid Derivatives
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