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Palladium-catalyzed allylic alkylation using chiral hydrazones as ligands
T Mino1, M Shiotsuki, N Yamamoto
1Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. tmino@planet.tc.chiba-u.ac.jp
The Journal of Organic Chemistry
|March 23, 2001
Abstract:
Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (4) with a dimethyl malonate-BSA-LiOAc system and its derivatives has been successfully carried out in the presence of a new chiral hydrazone ligands such as 2-(diphenylphosphino)benzaldehyde SAMP hydrazone (DPPBA-SAMP) (3a) in high yields with high enantioselectives.