Visible-Light-Promoted Formylation/Annulation of Isocyanides with Glyoxylic Acid Acetals for the Synthesis of Masked
Xinyu Lyu1, Peidong Cheng1, Qinyi Shen1
1Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, School of Petrochemical Engineering, Changzhou University, Changzhou213164, China.
Abstract:
Herein, we report a visible-light-promoted cascade formylation/annulation of isocyanides with glyoxylic acid acetals, which serves as the aldehyde source, to afford a diverse range of functionalized masked 2-formyl phenanthridines and quinolines. The protocol can be successfully scaled up to a 1 mmol synthesis, and the resulting products can be readily derivatized into corresponding aldehydes, alcohols, and esters in good yields.
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