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Cascade Synthesis of Pyridoquinazolinones: A Pd-Catalyzed Double C-N Bond Formation Strategy via Intramolecular

Priyanka Saikia1,2, Pranjal Gogoi1,2

  • 1Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat785006, India.

The Journal of Organic Chemistry
|September 11, 2026
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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