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Updated: May 14, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Pd(II)-Catalyzed Annulation of Alkynes with 4-Hydroxy-3-Maleimidecoumarin: One-Pot Construction of Multiple Rings
Kumud Sharma1,2, Abhilash Sharma3, Kashmiri Neog4
1Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
Abstract:
A Pd(II)-catalyzed cascade annulation of 4-hydroxy-3-maleimidecoumarin with alkynes has been demonstrated. This unique strategy highlights an interesting process for the cascade formation of three rings (three-, five-, and six-membered) of carbocycles and heterocycles through spiro-annulation followed by cyclization. This strategy offers an attractive platform for synthesizing various coumarin-fused complex structures in good yields. Additionally, six synthesized compounds have been unambiguously confirmed by single-crystal X-ray diffraction analysis.
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Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.