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Updated: Jan 28, 2026

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Published on: November 30, 2022
Pd-Catalyzed Suzuki Coupling Followed by Intramolecular Ipso-Friedel-Crafts Arylation Process: Cascade Synthesis of
Riju Moni Moran1, Kangkana Chutia1,2, Rajashree Bhuyan1,2
1Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
Abstract:
A Pd-catalyzed cascade process has been developed for the direct synthesis of hydroxylated fluorenes from o-bromophenyl-substituted p-quinone methides (p-QMs) and 3-hydroxy-substituted arylboronic acids. This cascade process comprises Suzuki coupling, followed by intramolecular ipso-Friedel-Crafts arylation, which affords the functionalized fluorenes in good yields. This protocol offers several advantages, including substrate versatility and high regioselectivity. Additionally, both symmetrical and unsymmetrical p-quinone methides participate smoothly in this cascade process.
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