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Updated: Aug 4, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
The first total synthesis of +-ratjadone
U Bhatt1, M Christmann, M Quitschalle
1Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, D-30167 Hannover, Germany.
Abstract:
The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis of structural analogues for biological target identification.
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