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Alzheimer's disease: current and future therapeutic perspectives
1McGill Centre for Studies in Aging, Montreal, Canada.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|March 27, 2001
Summary
Advances in understanding Alzheimer's disease (AD) pathophysiology through epidemiological and genetic studies offer new hypotheses for delaying progression. Future strategies include targeting disease milestones and predicting risk for prevention.
Area of Science:
- Neuroscience
- Genetics
- Epidemiology
Background:
- Alzheimer's disease (AD) pathophysiology understanding has advanced significantly.
- Population-based epidemiological, human genetic, and post-mortem studies have been crucial.
Purpose of the Study:
- To leverage a better understanding of AD pathophysiology for testable hypotheses.
- To identify therapeutic targets, including the conversion from mild cognitive impairment (MCI) to dementia.
- To explore future clinical capabilities for risk prediction and prevention advice.
Main Methods:
- Epidemiological studies
- Human genetic studies
- Post-mortem studies
Main Results:
- Improved understanding of AD pathophysiology.
- Identification of key disease milestones as therapeutic targets.
- Development of symptomatic drugs for AD patients.
Conclusions:
- New hypotheses for delaying AD progression are available.
- Therapeutic targets, such as MCI to dementia conversion, have been identified.
- Future clinical practice will include risk prediction and prevention strategies for AD.