Related Experiment Videos
Synthesis and properties of peptide nucleic acids containing a psoralen unit
1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, CREST, Japan Science and Technology Corporation (JST), Kyoto 606-8501, Japan.
Organic Letters
|March 27, 2001
Abstract:
We prepared the psoralen PNA unit from 8-methoxypsoralen and synthesized various PNAs containing psoralen by a typical (t)()Boc method. PNAs containing psoralen (P-PNA) at strand end formed a stable duplex with complementary DNA. The hybridization of P-PNA with complementary DNA resulted in a considerable decrease of the psoralen fluorescence.