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[Transient electrical birefringence study of the interaction between DNA and platinum compounds: cis-DDP, trans-DDP
1Laboratoire de biophysique, université de Nice, Sophia Antipolis, parc Valrose, 06108 Nice, France. georges.mallet@unice.fr
Pathologie-Biologie
|March 27, 2001
Abstract:
The interaction between DNA and the platinum compounds cis-DDP, trans-DDP and TDP has been studied in aqueous solution at pH 7.0 by transient electric birefringence (TEB). Data was obtained on the electro-optical characteristics and hydrodynamic properties of these solutions. The specific interactions between each of the three platinum compounds and DNA were differentiated, and their binding affinity for DNA phosphate sites was as follows, in decreasing order of importance: TDP >> cis-DDP > trans-DDP.
