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Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common

E K Dziadulewicz1, C S Walpole, C R Snell

  • 1Novartis Institute for Medical Sciences, London, UK. ed.dziadulewicz@pharma.novartis.com

Bioorganic & Medicinal Chemistry Letters
|March 27, 2001
PubMed

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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