Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNA localization: SHEdding light on the RNA-motor linkage.

S Kwon1, B J Schnapp

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

Current Biology : CB
|March 27, 2001
PubMed
Summary

Specific messenger RNAs (mRNAs) are distributed unevenly within cells using molecular motor proteins. Researchers identified She3p as a key adaptor protein connecting these motors to specific RNA molecules in yeast.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Expert-involved continuous renal replacement therapy device development: addressing user needs through human factors engineering.

Expert review of medical devices·2025
Same author

Ventriculophasic response in a horse with atrioventricular block.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025
Same author

How Neighborhood Structural and Individual Characteristics Affect Frailty Progression: Evidence from the China Health and Retirement Longitudinal Study.

The journal of nutrition, health & aging·2023
Same author

Feasibility Study for an Automated Engineering Change Process.

International journal of production research·2023

Area of Science:

  • Cell biology
  • Molecular genetics
  • Biochemistry

Background:

  • Specific messenger RNAs (mRNAs) undergo asymmetric cellular distribution.
  • This localization is crucial for cellular function and development.
  • Molecular motors moving along the cytoskeleton are involved in this process.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying mRNA localization.
  • To identify the specific proteins involved in linking mRNAs to molecular motors.
  • To understand the role of adaptor proteins in RNA transport.

Main Methods:

  • Studies were conducted in Saccharomyces cerevisiae (yeast).
  • Analysis of the RNA-motor linkage.
  • Identification and characterization of adaptor proteins.

Related Experiment Videos

Main Results:

  • The adaptor protein She3p was identified.
  • She3p acts as a linker between a type V myosin motor and specific ribonucleoproteins (RNPs).

Conclusions:

  • She3p plays a critical role in the asymmetric distribution of specific mRNAs.
  • This finding elucidates a key mechanism in RNA localization pathways.
  • The study provides insights into the regulation of gene expression through mRNA transport.