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Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Dialysis01:27

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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
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Hemodialysis I: Introduction01:25

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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

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Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
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Updated: Jan 17, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Expert-involved continuous renal replacement therapy device development: addressing user needs through human factors

J Choi1,2, C H Park1, H Lim1,2

  • 1Interdisciplinary Program in Bioengineering, Seoul National University Graduate School, Seoul, Republic of Korea.

Expert Review of Medical Devices
|September 16, 2025
PubMed
Summary
This summary is machine-generated.

Expert-led usability engineering created a user-centered continuous renal replacement therapy (CRRT) device. This approach significantly improved patient safety by reducing use-related risks and enhancing user satisfaction.

Keywords:
CRRT deviceexpert involvementmedical device developmentusability engineeringuse-related risks mitigation

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Area of Science:

  • Biomedical Engineering
  • Human Factors Engineering
  • Medical Device Design

Background:

  • Continuous renal replacement therapy (CRRT) devices are critical for critically ill patients.
  • Existing CRRT devices present significant usability challenges, leading to use-related risks and impacting patient safety.

Purpose of the Study:

  • To apply expert-involved usability engineering to develop a user-centered CRRT device.
  • To enhance patient safety by mitigating use-related risks in CRRT devices.

Main Methods:

  • A three-phase study involving 233 experts.
  • Phase 1: Online survey (n=204) to identify user needs and risks.
  • Phase 2 & 3: Iterative prototype refinement, expert review, heuristic evaluation, and validation with ICU nurses (n=16) in simulated environments.

Main Results:

  • User needs and risks were translated into user interface requirements.
  • The final prototype achieved high user satisfaction scores (e.g., Overall User Experience 4.29 ± 0.53).
  • Validation confirmed effective mitigation of use-related risks, with 8 use errors and 48 difficulties identified for further refinement.

Conclusions:

  • Systematic expert involvement in usability engineering successfully developed a CRRT device.
  • The developed CRRT device effectively mitigated use-related risks and achieved high user satisfaction.
  • This highlights the value of integrating expert insights into medical device development.