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Artificial nutrition and bone marrow transplantation
M Candusso1, D Faraguna, P Landini
1Servizio di Farmacia, IRCCS Burlo Garofolo, Trieste, Italy.
Haematologica
|March 28, 2001
Summary
Parenteral nutrition (PN) is crucial for bone marrow transplant (BMT) patients needing supportive care. Proper nutritional support improves survival by maintaining hydration and reducing lean body mass loss.
Area of Science:
- Oncology
- Hematology
- Clinical Nutrition
Background:
- Parenteral nutrition (PN) is vital for supportive therapy in bone marrow transplant (BMT) patients.
- Central catheters are essential for administering transfusions, antibiotics, and nutrition.
- Adequate nutritional support enhances hydration, minimizes lean body mass loss, and improves comfort and survival.
Purpose of the Study:
- To highlight the importance of parenteral nutrition in bone marrow transplant (BMT) patient care.
- To discuss metabolic complications associated with PN in BMT and critical care settings.
- To emphasize strategies for preventing PN-related complications, particularly liver disease.
Main Methods:
- Review of the role of PN in BMT supportive care.
- Identification of metabolic risks associated with PN, including electrolyte and glucose disturbances.
- Discussion of liver disease as a complication of PN in cancer patients.
Main Results:
- PN is mandatory for BMT patients unable to eat or absorb nutrients.
- Metabolic complications, especially electrolyte and glucose disturbances, are frequent post-BMT.
- Liver disease is a significant complication, preventable by avoiding prolonged enteral fasting.
Conclusions:
- Parenteral nutrition plays a central role in BMT supportive therapy.
- Close monitoring for metabolic complications is essential in critical care BMT patients.
- Preventing liver disease involves avoiding prolonged enteral fasting in cancer patients receiving PN.