Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural control of ocular immune privilege.

J W Streilein1, S Okamoto, Y Sano

  • 1Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA. waynes@vision.eri.harvard.edu

Annals of the New York Academy of Sciences
|March 28, 2001
PubMed
Summary

The eye’s immune privilege, which prevents inflammation, is controlled by the nervous system. Neural pathways and eye-specific factors regulate immune responses, protecting vision.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old.

Global health, epidemiology and genomics·2018
Same author

Association between Body Mass Index and All-Cause Mortality among Oldest Old Chinese.

The journal of nutrition, health & aging·2018
Same author

Comparison of Health and Risk Factors of Older, Working-age Australians, Italians and Italian-born Migrants to Australia, with Data from an Italian (PASSI), and an Australian (SAMSS) Risk Factor Surveillance System.

Journal of immigrant and minority health·2017
Same author

Population levels of wellbeing and the association with social capital.

BMC psychology·2017
Same author

Chilli consumption and the incidence of overweight and obesity in a Chinese adult population.

International journal of obesity (2005)·2017
Same author

Feeling angry about current health status: using a population survey to determine the association with demographic, health and social factors.

BMC public health·2016

Area of Science:

  • Ophthalmology
  • Neuroimmunology
  • Immunology

Background:

  • Ocular immune privilege protects the eye from inflammation.
  • Antigen injection in the eye causes unique immune responses (Anterior Chamber-Associated Immune Deviation, ACAID).
  • The ocular microenvironment suppresses inflammation.

Purpose of the Study:

  • To investigate the neural control of ocular immune privilege.
  • To understand the role of neuropeptides and light in immune responses within the eye.

Main Methods:

  • Analysis of neuropeptides in aqueous humor.
  • Assessment of ACAID after corneal nerve severance.
  • Evaluation of ACAID under light deprivation.

Main Results:

Related Experiment Videos

  • Aqueous humor contains immunosuppressive neuropeptides (alpha-MSH, VIP, CGRP).
  • Severing corneal nerves disrupts ACAID, which recovers upon nerve regrowth.
  • Light deprivation impairs ACAID induction, indicating photoreceptor involvement.

Conclusions:

  • Ocular immune privilege is significantly influenced by neural control.
  • Neuropeptides and light-sensitive pathways play crucial roles in regulating intraocular immunity.
  • Neural elements are essential for both the induction and expression of immune privilege in the eye.